PRMT6 and hepatocellular carcinoma: HEY1 is a downstream target of the NOTCH signaling pathway, and its increased expression may result in an increase in the number of LCSCs and the chemoresistance of hepatocytes, thereby promoting HCC development.48 The protein arginine methyltransferase 6 (PRMT6) is methylated and linked to arginine-100 (R100) of c-Raf to inhibit MAPK signaling.