Most notably, the amelioration of tumor hypoxia further heightened the effectiveness of ICG in PDT and triggered ICD, resulting in an antitumor immune response, the application of HSA/ICG NP-coated Syne (S/HSA/ICG) brings about a synergistic inhibition of both local and metastatic tumors in a murine model of 4T1 mTNBC. This evidence concerns the gene ALB and metastatic neoplasm.