CD44 and breast cancer: In a study, Yang and colleagues fabricated hyaluronic acid-coated lipoid-polymer nanoparticles for the co-delivery of PTX and curcumin,44 for the elimination of breast CSCs and non-CSCs to destroy breast tumors.106 HA was the targeting moiety used to target CD44 expressed on the breast cancer cells as HA specifically interacts with CD44 leading to enhance cellular uptake of HA-hybrid nanoparticles.