Therefore, we conducted a mendelian randomized study to explore the causal relationship between PD-1/PD-L1 and five specific types of CHD (chronic ischemic heart disease, acute myocardial infarction, angina pectoris, coronary atherosclerosis, and unstable angina pectoris), complemented by GSEA for further validation. Here, PDCD1 is linked to myocardial infarction.