Though our results did not support a causal association between PD-1/PD-L1 and acute myocardial infarction, angina pectoris, coronary atherosclerosis, as well as unstable angina pectoris, further investigations are needed to clarify the mutual effect between PD-1/PD-L1 and CHD, as well as predictive models that detect intricate relationships and interactions among genetic variations, environmental influences, and the risk of CHD. This evidence concerns the gene CD274 and acute myocardial infarction.