Genetically predicted high levels of VEGF-A [OR = 1.025 (95%CI: 1.004–1.047), PFDR = 0.060] and VEGF-D [OR = 1.080 (95%CI: 1.039–1.123), PFDR = 0.001]] were associated with an increased risk of atrial fibrillation, while no causal relationship was observed between VEGF-C (PFDR = 0.419), VEGFR-2 (PFDR = 0.784), and VEGFR-3 (PFDR = 0.899) and atrial fibrillation risk. Here, VEGFD is linked to atrial fibrillation.