The T/M ratios in [68Ga]Ga-HN11-1 and [68Ga]Ga-HN11-2 groups in the A549-PD-L2 tumor xenograft models were 5.08 ± 0.84, 10.31 ± 2.18, 27.92 ± 1.76, and 2.60 ± 0.60, 5.44 ± 1.12, and 11.81 ± 1.93 at 10, 30, and 60 min, respectively (Fig. 3C), both groups exhibited T/M ratios higher than those observed in the A549 tumor xenograft models after injection of [68Ga]Ga-HN11-1 to varying degrees (Fig. S7B). Here, PDCD1LG2 is linked to neoplasm.