For example, the overexpression of PAICS, which is involved in GO:0043473, in melanocytes could inhibit tumor cell apoptosis and promote the growth by regulating related signaling pathways [32]; and COX6A2 in GO:0004129 is also implicated in the pathogenesis of melanoma through the cytochrome c oxidase subunit [33]. The gene discussed is COX6A2; the disease is neoplasm.