Recent studies have shown that increasing the level of this marker is not a direct factor in increasing the risk of pre-eclampsia, but rather increase the affinity of MUC16 to some immunological cells, such as natural killer cells and monocytes, can involve the pathological process leading to hypertension and proteinuria and eventually pre-eclampsia (24, 18). This evidence concerns the gene MUC16 and hypertensive disorder.