Normal cognitive decline has been related to reduced synapse formation, expression of neuroprotectors like neurotrophins, altered neurogenesis and plasticity (Burke et al., 2010; Gallagher and Nicolle, 1993; Encinas et al., 2011; Ben Abdallah et al., 2010; Lu et al., 2005; Mattson and Arumugam, 2018). The gene discussed is BDNF; the disease is Mental deterioration.