Moreover, biomarkers of both epithelial [surfactant protein-D (SP-D) and soluble receptor for advanced glycation end products (sRAGE)] and endothelial [angiopoietin-2 (Ang-2) and von Willebrand factor (vWF)] cell injury have been identified in ARDS (Stevens et al., 2024). Here, ANGPT2 is linked to acute respiratory distress syndrome.