Produced by resident lung cells (such as pulmonary epithelial cells and platelets during lung inflammation) (Jeyaseelan et al., 2005), Cxcl5 plays a key role in controlling chemokine clearance (Mei et al., 2010) and can negatively regulate neutrophil influx into the lungs by affecting the concentration of other chemokines in the bloodstream (Koltsova and Ley, 2010; Mei et al., 2010; Guo et al., 2021). The gene discussed is CXCL5; the disease is inflammation.