NR3C2 and Obesity: Female MSEW mice fed a HFD show exacerbated obesity and aldosterone production compared with diet-matched control mice, while chronic treatment in adulthood with spironolactone, a mineralocorticoid receptor antagonist, resulted in loss of fat mass coupled with increased glycerol efflux and decreased adipocyte size in MSEW females, but not in HFD controls (24).