TNF and neoplasm: It is an established fact that NF-κB activation in macrophages in the onset of inflammation is related to the expression of proinflammatory genes(e.g.TNF-α, IL-β), whereas NF-κB activation resolution phase is associated with the expression of anti-inflammatory genes(e.g. TGF-β1).In TME, similar to this phenomenon, TAMs driven by NF-κB during the beginning of the tumor tend to produce proinflammatory cytokines such as TNF-α and IL-β to suppress tumor growth.