Another report found that in the duration of antitumor immunity by inducing interferon (IFN) response, the activation of NF-κB by a long noncoding RNA-IFN-responsive nuclear factor-κB activator (IRENA) in M1 macrophages and increased secretion of pro-inflammatory cytokines, which promote breast cancer chemoresistance (154). The gene discussed is NFKB1; the disease is breast cancer.