Although active NF-κB in immune cells and tumor cells have a crucial role in anti-tumor activity, constitutive activation of NF-κB in tumor cell is recognized as a promoter of pro-survival and angiogenic factors, such as BCL-XL,surviving,MCL1,VEGF and MMP9,which are also regulated by STAT3 (5). The gene discussed is MCL1; the disease is neoplasm.