In breast cancer cells, the involvement of NF-κB extends to mediating the expression of key EMT transcription factors, including Slug, Sip1, and Twist1,alongside NF-κB-dependent regulation of ZEB-1/ZFHX1A and ZEB-2/ZFHX1B, also known as Smad-interacting protein (78, 80). This evidence concerns the gene ZEB2 and breast cancer.