In many types of tumor,NF-κB and STAT3 are constitutively activated in response to the upstream autocrine and paracrine factors that are produced within the tumor microenvironment.When receiving the stimulis such as cytokines and growth factors, NF-κB and STAT3 influence the progression of tumor through regulating repression of cytokines, growth factors in tumor cells and some other inflammatory/immune mediators (115). This evidence concerns the gene NFKB1 and neoplasm.