Recent studies have demonstrated that, in a head and neck squamous cell carcinoma (HNSCC) model, the ablation of the CHMP2A gene precipitates NF-κB activation in neoplastic cells, culminating in augmented chemokine secretion that facilitates NK cells migration towards the tumor microenvironment (17). The gene discussed is CHMP2A; the disease is head and neck squamous cell carcinoma.