8 metabolites significantly decreased in MS: 4 (myo-inositol, isoleucine, leucine, glutamine) had higher specificity than OCB for MS diagnosis.9 biomarkers outperformed OCB as predictor of MS (CCN5, CDCC80, NTN1, vWF, DKK4, SOST, ERBB3, IGL4, and IGKV1-5).All significantly decreased in MS vs non-MS except for IGL4 and IGKV1-5, which were increased. This evidence concerns the gene CCN5 and myeloid sarcoma.