CD4 and autoimmune disease: MS vs other autoimmune diseases: besides parameters such as intrathecal plasma cells concomitant with IgG synthesis, the analyses identified intrathecal IgA and IgM synthesis.There were other disease-specific parameters, such as alterations in circulating peripheral blood CD56bright NKcells and intrathecal lactate concentrations in NMOSD; circulating CD4+ and CD8+ T cells in Susac Syndrome; and circulating and intrathecal lymphocytes, intrathecal NK T cells, monocytes, and CD14+CD16+ monocytes in AE.