TIGIT and melanoma: Although Tex herein displayed a typical exhausted state, which was featured by high expression of inhibitory markers (Tox, Havcr2, Lag3, Pdcd1 and Tigit) and low expression of effector markers (Tbx21 and Ifng), their high expression of Gzmk and intermediate expression of Lag3 among other genes could term them in a different way as predysfunctional cells identified in a melanoma cohort (32) (Figure 5C).