CD4 and neoplasm: To explore which cell types express the marker genes that we identified to construct our matrix extraction risk characteristics, based on the cell annotation information of a single-cell dataset (GSE161529), we calculated the enrichment degree of matrix risk genes with positive (positive score) and negative (negative score) ratios in specific cell types and found that in negative scores, CD4 Tconv and endothelial, epithelial, fibroblast, malignant, mono/macro, and pericyte, and plasma cells differed significantly between tumor and normal cells.