These shrimp allergy-associated genes include HLA-DQ (rs9275596), HLA-DRB1 (HLA-DRB1*04:05-HLA-DQB1*04:01), IL-13 (rs20541, and IL13 rs1800925) (45, 46), and food allergy -associated gene TLR4 rs4986790 (Asp299Gly) (47). The gene discussed is HLA-DRB1; the disease is allergic disease.