Moreover, several signature sets associated with TLS had shown positive prognostic predictive value, including plasma cell signatures in ovarian cancer; T follicular helper cell signatures in squamous cell carcinoma of the head and neck; and a variety of gene signatures (including CCL5, CXCL9, CXCL10, and CXCL13) associated with lymph chemokines in colorectal, melanoma, and breast cancer (5, 26, 27). The gene discussed is CXCL13; the disease is breast cancer.