Moreover, several signature sets associated with TLS had shown positive prognostic predictive value, including plasma cell signatures in ovarian cancer; T follicular helper cell signatures in squamous cell carcinoma of the head and neck; and a variety of gene signatures (including CCL5, CXCL9, CXCL10, and CXCL13) associated with lymph chemokines in colorectal, melanoma, and breast cancer (5, 26, 27). This evidence concerns the gene CCL5 and melanoma.