PTGS2 and neuroblastoma: In line with that, in an in vivo study, sulforaphane was observed to reduce inducible nitric oxide synthase (iNOS), proinflammatory levels (IL-1β, IL-6), cyclooxygenase-2 (COX-2), and nuclear factor (NF)-κB p-p65 in mouse neuroblastoma N2a cells expressing APPswe (Zhao et al. 2018).