Remarkably, an in vitro investigation examined the potential synergistic impact of combining ibuprofen and sulforaphane on the down-regulation of DNA binding activity of the p50 subunit of NF-κB and the subsequent reduction in cell viability in human pancreatic cancer Panc-1 and MIA PaCa-2 cells. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.