HPGDS and Alzheimer disease: Sulforaphane has demonstrated significant biological activities that have the potential to improve AD, including acting as a substrate for glutathione S-transferase, stimulating the immune system, antagonizing neurotransmitters, providing protection against chemical damage, preventing the onset of cancer, activating transient receptor potential ankyrin 1 (TRPA1) receptors, and enhancing the sensitivity of cells to chemotherapy.