“Amyloid precursor protein catabolic process”, regulation of apoptotic signaling pathway”, and “positive regulation of nitric oxide biosynthetic process” were the main pathways, while NFKB1, SP1, and RELA, hsa-miR-17-5p, hsa-miR-16-5p, and hsa-miR-26b-5p were key transcription factors and miRNAs implicated in sulforaphane protective effects against AD. Here, NFKB1 is linked to Alzheimer disease.