ALB and neoplasm: This may be due to steric hindrance or an increased intermembrane distance between the Vγ9Vδ2 T-cell and TAA+ tumor target cell interfering with efficient immune synapse formation (46) as a result of either the Fc domain or a bound albumin molecule, translating into higher EC50s for degranulation and tumor lysis compared to the (non-Fc, non-anti-albumin VHH bound) TAA-Vδ2hi-lo bsVHH.