Similar enhancement of β-catenin target gene expression was reported as a consequence of Tiam1 association with the β-catenin/TCF transcription factor complex (Buongiorno et al., 2008); increased expression of Tiam1 was previously shown to stimulate colon cancer cell invasion (Liu et al., 2005), migration, and tumor formation and metastases in CRC animal models (Minard et al., 2005; Malliri et al., 2006). Here, TIAM1 is linked to malignant colon neoplasm.