In the course of these studies, our laboratory made the serendipitous observation that activating M3R upregulated βPix/β-catenin colocalization in both the cytoplasm and nucleus of colon cancer cells, providing a potential mechanism whereby M3R modulates the expression of β-catenin target genes, including the genes encoding cMyc (MYC), cyclin D1 (CCND1), and cyclooxygenase-2 (PTGS2) (Cheng et al., 2023). The gene discussed is PTGS2; the disease is colonic neoplasm.