Ectopic expression of Tiam1 in SW480 cells induced morphological changes and increased migration, underscoring Tiam1’s role in promoting the metastatic phenotype of CRC cells through Rac1 activation and subsequent cytoskeletal reorganization and enhancement of cell adhesion (Kotelevets and Chastre, 2020; Song et al., 2023). Here, TIAM1 is linked to colorectal carcinoma.