HIF-1α: hypoxia-inducible factor 1-alpha; CAR: chimeric antigen receptor; PD-1: programmed cell death protein 1; PD-L1: programmed death-ligand 1; TIL: tumor-infiltrating lymphocyte; T-VEC: talimogene laherparepvec. This evidence concerns the gene PDCD1 and neoplasm.