Our patient with a deletion on chromosome 10p12.31p11.22 developed hydrocephalus required VP shunt like the case described by DeSanto et al. that showed bilateral prominence of the subarachnoid spaces consistent with benign external hydrocephalus and stable ventriculomegaly seen on brain MRI and had WAC loss-of-function mutations with 10p11.23 microdeletion [1]. This evidence concerns the gene WAC and Hydrocephalus.