The possible explanations for malfunction beyond the lungs are endothelial injury and dysregulated innate immune system through the exertion of IL-6, interferon gamma (IFN-γ), IL-10, and tumor necrosis factor (TNF), which consequently leads to T-cell overproduction and B-cell deficiency and lasting cytokine storm [5]. The gene discussed is IFNG; the disease is B cell deficiency.