MOG and optic neuritis: Diagnosis requires fulfillment of three criteria: (1) A core demyelinating event, such as optic neuritis, myelitis, acute disseminated encephalomyelitis (ADEM), cerebral unifocal or multifocal deficits, brainstem or cerebellar deficits, or cerebral cortical encephalitis with the presence of seizures; (2) positive MOG IgG test using a cell-based assay with supporting clinical or radiographic findings; and (3) the exclusion of other better diagnoses, including MS [9].