While relevant literature on image-negative MOG antibody encephalitis is limited, similar reports on the existence of this specific disease phenotype have been published. Macaron and Ontaneda present the case of a 57-year-old man with a one-week history of subacute urinary retention, which progressed to rapidly worsening symmetric paraparesis and reduced sensation in both lower extremities up to the umbilicus. Despite significant clinical symptoms, CNS MRI conducted 48 hours after symptom onset was normal, except for two non-enhancing supratentorial T2 abnormalities. The gene discussed is MOG; the disease is viral encephalitis.