These drugs decrease the activation of neuronal cells through mechanisms such as blocking sodium channels (preventing the depolarisation of neurons), blocking calcium channels (preventing the release of neurotransmitters), enhancing potassium channels (hyperpolarising neurons), inhibiting glutamate excitation (discussed in the pathophysiology of epilepsy and seizures section), and promoting GABA inhibition (discussed in the pathophysiology of epilepsy and seizures section). Here, KCNA3 is linked to epilepsy.