Although endogenous GLP-1 is short-lived (half-life of ~2 minutes), long-lasting GLP-1RAs have half-lives of hours to days16 and maintain their efficacy after repeated pharmacological doses.17 GLP-1RA treatments have shown to reduce albumin excretion in people with T2D,18 in addition to enhancement of diuresis and natriuresis.19 Although the canonical GLP-1R is expressed in the kidney, attempts to uncover its localized action have been challenging. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.