HMGB1 binds to NF3 and activates the NF‐κB pathway, leading to IL‐10 (IL‐8) secretion, which recruits neutrophils and induces further NET formation via the PI3K/AKT/ROS axis, while targeting NET formation or IL‐8 secretion inhibits glioma progression.321. The gene discussed is CXCL8; the disease is glioma.