Intriguingly, SOX9 has been reported to be activated by the ErbB pathway in glioblastoma before.[59] As both ErbB and Wnt pathways have been implicated in GBC oncogenesis,[8] it would be interesting to further study the potential positive feedback loop involving the two signaling pathways and the SOX9‐TCF7L2 circuitry, which may uncover additional upstream regulatory mechanisms and therapeutic targets. The gene discussed is TCF7L2; the disease is glioblastoma.