On the other hand, the 17q24.3 region, encompassing the SOX9 gene, has been reported to be genetically amplified in patients with GBC.[60] Moreover, the SOX9 locus was also found to be significantly amplified in multiple GBC cell lines according to the genomic profiling data from the DepMap database (data not shown).[61] These findings are in line with the notion that the prominent driver gene expression can be altered in cancer cells via multiple mechanisms. This evidence concerns the gene SOX9 and cancer.