To be noted, none of the cancer types and benign CC tissues[47] exhibits as strong correlation patterns of SOX9 and TCF7L2 as GBC in all analysis, further underscoring the specificity of SE‐driven SOX9‐TCF7L2 CRC module in GBC (Figure S3B–D, Supporting Information). Here, TCF7L2 is linked to cholangiocarcinoma.