With integrative analysis of whole genome CRISPR screening data from DepMap Project, GBC RNAseq data, and the Coltron prediction results, five CRC TFs (SOX9, TCF7L2, FOXA1, TGIF1 and HES1) were found to meet all our defined criteria for gene expression and tumor‐dependency levels (Figure 2B). The gene discussed is SOX9; the disease is colorectal carcinoma.