Among these factors, tumor stage, liver metastasis, surgical margin and SOX9&TCF7L2 staining (double‐high versus double‐low subgroup, HR = 2.23, 95% CI 1.10‐4.53, p = 0.026) remained significantly associated with OS in the multivariable analysis (Figure 7F). The gene discussed is SOX9; the disease is neoplasm.