When we individually knocked down each of the five CRC TFs in NOZ, a GBC cell line, to measure the effects on the transcription of others, only SOX9 and TCF7L2 were found to exhibit mutual transcriptional dependency, as silencing either of them resulted in a significant decrease of both of their mRNA levels (Figure 2F). The gene discussed is TCF7L2; the disease is colorectal carcinoma.