Despite these in vitro findings, however, the absence of Piezo1 prevents autoimmune and alloimmune inflammation in in vivo models of experimental autoimmune encephalomyelitis (EAE), IBD, and graft-vs-host disease (GvHD) with a decrease in the CD4+ T-cell effector memory (TEM) population. Here, PIEZO1 is linked to inflammatory bowel disease.