Out of the 60 children with CAH, 6 had NC–CAH by genotype but a clinical phenotype consistent with intermediate between NC and salt virilizing clinical phenotype, as all 6 had suboptimal cortisol secretion in response to high-dose ACTH stimulation test and signs of virilization (penile or clitoral enlargement) and advanced bone age. This evidence concerns the gene POMC and congenital adrenal hyperplasia.