To determine if ASC/NLRP3 specks levels might have diagnostic or prognostic value in AOSD, we compared ASC/NLRP3 specks with C‐reactive protein (CRP) levels and SAS (divided into mild [0–2, n = 21], moderate [3–4, n = 35], and severe SAS [5–7, n = 47]). Here, NLRP3 is linked to adult-onset Still disease.