Despite each cohort having similar proportions of germline variants in CHIP‐associated genes (AOSD#2 63.3%; AOSD#3 73.3%; HCs 66.3%), 22.0% (13 of 59 variants) of these were enriched in AOSD cases, whereas only 4.7% (2 of 43 variants) were enriched in HCs. The gene discussed is STUB1; the disease is adult-onset Still disease.