ALPK1 and adult-onset Still disease: Genes ALPK1, PLCG2, TRAP1, and NOD2 had the highest variant frequency within this panel among AOSD cases (Figure 1B), and reoccurring variants of interest include NOD2 c.2183C>T and PLCG2 c.1444T>C; each were identified in three separate AOSD cases (Figure 1C).