NLRP3 and AIDS: For example, somatic gain‐of‐function (GOF) mutations in autoinflammatory genes such as NLRP3 and NLRC4, which arise within bone marrow and are restricted to myeloid lineage, result in spontaneous activation of the respective inflammasomes with subsequent excessive release of IL‐1β and IL‐18 and late‐onset autoinflammatory disorders (AIDs).7, 8