This was most prominent in treatment‐resistant patients from cohort AOSD#3 who also had higher ASC/NLRP3 specks in comparison with patients with AIDs typically associated with NLRP3 inflammasome activation, such as cryopyrin‐associated periodic syndrome (CAPS) and Schnitzler syndrome (Figure 4A). Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.