NLRP3 and myelodysplastic syndrome: Furthermore, in the premalignant bone marrow state clonal hematopoiesis of indeterminant potential (CHIP), which often precedes MDS, certain somatic mutations in bone hematopoietic stem cells have been associated with NLRP3 inflammasome activation, release of IL‐1β, and a general proinflammatory state.11