ASC/NLRP3 specks levels and type I IFN scores were significantly elevated in AOSD cases compared with HCs (P = 0.0001 and 0.0015, respectively), in addition to several cytokines: interleukin (IL)‐6 (P < 0.0001), IL‐10 (P < 0.0075), IL‐12p70 (P = 0.0005), IL‐18 (P < 0.0001), IL‐23 (P < 0.0001), IFN‐α2 (P = 0.0009), and IFNγ (P = 0.0002). This evidence concerns the gene NLRP3 and adult-onset Still disease.