Tuberous sclerosis (TS) is a rare autosomal dominant disorder characterized by pathogenic mutations in TSC1 or TSC2 genes, leading to the formation of hamartomas and benign tumors in the CNS or outside it (e.g., fibromas, angiofibromas, angiomyolipomas, and cardiac rhabdomyomas).5 The gene discussed is TSC2; the disease is tuberous sclerosis.