ACE and diabetes mellitus: These findings agree with previous review studies that demonstrated the beneficial effects of CVD polypills with the right combination in the primary prevention of CVD and diabetes in MetS patients.14 Recently, a meta-analysis suggested that using blood pressure-lowering drugs, especially angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for five years, reduces the risk of new-onset type 2 diabetes by 16%, while the use of β-blockers and thiazide diuretics increased this risk by 1.20% and 1.02%, respectively.