IFNG and melanoma: Melanomas can also selectively attract immune inhibitory cells such as Tregs and MDSCs; or show low antigen presentation and recognition due to low mutational burden and loss of MHC class I. Melanoma may also present insufficient mature dendritic cells (DCs) in the TME that can limit the generation of potent T cell responses; and have mutations such as in the JAK/STAT pathway that decrease IFNγ signaling sensitivity (reviewed in [41, 42]).