NOTCH2 and neoplasm: Loss of Notch2 in CD8+ T cells (but not of Notch1), has been shown to promote tumor growth in mice [18]; and blockade of nuclear translocation of Notch2 intracellular domain (NIC), the active form of Notch, inhibits the cytotoxic efficacy of CD8+ T cells on hepatocellular carcinoma [19].