ZEB1 and posterior cortical atrophy: Additionally, MUC1-C can directly bind to nuclear factor kappa B (NF-κB) p65, promoting the activation of NF-κB p65 target genes (enhancer of zeste homolog 2) EZH2 and zinc finger e-box-binding homeobox 1 (ZEB1) to facilitate EMT and stemness as well as epigenetic reprogramming in PCa [150, 151].