MUC1-C is able to interact with E2F transcription factor 1 (E2F1) to induce the expression of esBAF subunit and activate the expression of notch receptor 1 (NOTCH1) and nanog homeobox (NANOG) genes to participate in CSC stemness of PCa cells [152, 153]. The gene discussed is E2F1; the disease is posterior cortical atrophy.