MUC1-C can activate the interferon gamma receptor 1 (IFNGR1) gene by forming a complex with BAF, upregulate the expression of STAT1 and interferon regulatory factor 1 (IRF1), and directly regulate the expression of IRF1 through PBAF, controlling the downstream expression of indoleamine 2,3-dioxygenase 1 (IDO1), tryptophanyl-TRNA synthetase (WARS), prostaglandin E synthase (PTGES), interferon-stimulated protein 15 (ISG15), and serpin family B member 9 (SERPINB9), thus participating in immunosuppression of PCa cells [155]. Here, WARS1 is linked to posterior cortical atrophy.