POU3F2 and posterior cortical atrophy: Studies have found that MUC1-C can directly bind to the MYC HLH/LZ structural domain to form the MUC1-C/MYC complex, which occupies the brain-2 (BRN2) promoter and induces the expression of BRN2 and downstream SOX2, thereby regulating the NE phenotype of PCa cells [147].