While total GSK3β was not affected by diets, we observed a significant increase in the inactivated form of GSK3β (phosphorylated at Ser-9) in 3xTg-AD mice under the DHA + EPA diet compared to those who received control or DHA diets (−49%, P < 0.05; −40%, P < 0.05; respectively) (Fig. 4E–F). This evidence concerns the gene GSK3B and Alzheimer disease.