Furthermore, BRCA1 gPV are associated to rapidly increasing BC at a very young age, accounting for about 5–10 % of all BC and 13 % of triple negative BC, with a 42 years median age at onset compared to 56 years in the general population Another interpretation could be the presence of a “de novo” gPV, mostly related to young age of BC onset [21]. Here, BRCA1 is linked to breast cancer.