CREB1 and graft versus host disease: Furthermore, the data of weight loss (Figure 5C), GVHD clinical score (Figure 5D), and histopathologic damages (Figures 5E and 5F) confirmed that CD1c+ B cells generated from the PKA/CREB axis-dependent induction system can also alleviate the clinical symptoms, decrease inflammatory cell infiltration, and reduce tissue injury in mice with GVHD.