EPHB4 and head and neck squamous cell carcinoma: Here, we sought to determine the effects of EphB4 on distant metastasis using two orthotopic models of HNSCC in the context of RT: the MOC2 (C57BL/6J) cell line and the LY2 (BALB/c) cell line, with either control or EphB4 shRNA knockdown [18].