SMAD3 and cancer: Additionally, our cell line RNA sequencing data in MOC2 ephrinB2 knockout cells compared to controls showed lower expression of EMT-related genes such as Smad3, Smad4, TGFb3, TGFBR2, BMP7, Tiam1, Foxc1, Fermt2, Bambi, Notch1, and TGFBR1 (Fig. 2E, F) which are typically associated with enhanced migratory and invasive capacities of cancer cells [58–62].