NOTCH1 and cancer: Comparison of transcriptomic changes between MOC2 control and EphB4 knockout cell lines also showed higher expression of TGF beta receptors 1 and 2, NOTCH1, and FOXC1, a transcription factor implicated in cancer cell plasticity, treatment resistance, invasion, and epithelial-mesenchymal transition (EMT) (Fig. 2E) [39, 40].