Using the ephrinB2fl/flTie2Cre (ephrinB2 KO) mouse model (Fig. 4A) [18] implanted with MOC2 cancer cells, we found that deletion of vascular ephrinB2 coupled with RT significantly reduced local tumor growth compared to wild-type (WT) hosts (Fig. 4B, Supplementary Fig. 5). This evidence concerns the gene EFNB2 and cancer.