This supports a model according to which Legionella ApaH/LphD/Smh1 are capable of deacetylating Acss2 in the nucleus/cytosol resulting in its activation and thereby generation of nuclear acetyl-CoA which can be used by KAT7 to acetylate histone H3K14 resulting in modulating of gene expression to promote an efficient infection. The gene discussed is ACSS2; the disease is infection.