TOMM40 and hepatocellular carcinoma: Consistent with prior studies in HeLa cells and C. Elegans [14,15], knockdown (KD) of TOMM40/TOMM40 in human hepatoma HepG2 cells (Figure 1B and C) resulted in reduction of basal and maximal respiration and ATP production as well as proton leak (Figure 1F–J) compared to non-targeting control (NTC).