MAPT and Alzheimer disease: It has been suggested that elevated tau protein accelerates the process of neurodegeneration, making laminar astrocytes more vulnerable to degeneration.26, 27In an AD investigation, Lee et al. discovered that patients with greater CSF tau protein levels had thinner LC.28In a study using OCT, Kayabaşi et al. injected Aß-binding protein in patients with MCI and found more inclusion cells in the retina when compared to healthy controls.29We expanded these findings by studying and comparing hippocampal volume in patients with AD and MCI.