Solid tumors can be classified into four types of TIME based on the expression of PD-L1 and tumor-infiltrating lymphocytes (TIL) (mainly based on CD8+ T cells): PD-L1-/TIL- (type I); PD-L1+/TIL+ (type II); PD-L1-/TIL+ (type III); PD-L1+/TIL- (type IV). Here, CD274 is linked to neoplasm.