The PNI score indicated that KRASG12D‐related PDAC was associated with increased nerve density and severity of PNI compared to other KRAS subtypes, whereas inhibition of EV secretion in Rab27a‐knock out (KO) mice suppressed the severity of neural infiltration in PANC‐1‐induced tumor tissues (Figures 1H–I and S2P, Supporting Information). Here, RAB27A is linked to neoplasm.