CD109 and neoplasm: Similarly, compared to the PANC‐1‐EVvector, PANC‐1‐EVcircPNIT was significantly enriched in the nerves of primary tumor tissue, and the CD109 neutralizing antibody effectively inhibited the accumulation of EV in nerves (Figure 5L,M), indicating that CD109 mediated the targeted delivery of KRASG12D PDAC‐derived EVs to neurons.