Extension of axons is reportedly accompanied by the expression of receptors that promote cancer‐neuron crosstalk to achieve local invasion and metastasis.[3, 20] Thus, the expression levels of core molecules involved in PNI‐related pathways in neurons were evaluated, and the results showed that the expression of only GFRα1 and RET was positively correlated with the expression of EV‐packaged circPNIT in DRG cells (Figure S8O, Supporting Information). Here, GFRA1 is linked to cancer.