Moreover, in both OVCAR3 and OVCAR8 cells, as well as their mouse xenograft tumors, we observed significant changes in the expression of downstream target genes of the Wnt/β‐catenin pathway, including those associated with ovarian cancer stem cells (OCSCs) after SPC25 overexpression or knockdown (Figure 2K; Figure S4F,G, Supporting Information). Here, SPC25 is linked to ovarian cancer.