SPC25, involved in the formation of the Ndc80 complex, mediates the interaction between microtubules and centromeres, ensuring accurate mitotic processes.[15, 16] Moreover, SPC25, overexpressed in various malignancies, is related to poor prognosis.[17, 52, 53] However, the molecular mechanisms underlying the nontraditional physiological functions of SPC25, particularly in the mediation of tumor malignancy progression, have not been reported. This evidence concerns the gene NDC80 and neoplasm.