CMTM6 belongs to the chemokine‐like factor‐like MARVEL transmembrane domain‐containing family (CMTM)[5] and is mainly recognized as a critical regulator of programmed cell death 1 ligand 1 (PD‐L1).[6] CMTM6 regulates PD‐L1 by inhibiting its ubiquitination,[6] thus preventing its lysosome‐mediated degradation in recycling endosomes.[7] Previous studies have focused on the effect of CMTM6 on antitumor immunity,[8] and its broader role in tumor development and drug resistance has been recently revealed. This evidence concerns the gene CD274 and neoplasm.