CMTM6 is highly expressed in gliomas and indicates poor prognosis.[9] It also enhances tumor stemness in head and neck squamous cell carcinoma.[10] Regarding chemoresistance, CMTM6 promotes cisplatin resistance by regulating the Wnt signal pathway through the ENO‐1/AKT/GSK3β[11] and AKT/c‐Myc axes.[12] CMTM6 could repress p21 ubiquitination to regulate chemoresistance in hepatocellular carcinoma.[13] Nevertheless, the precise role of CMTM6 in the chemotherapy resistance of PDAC remains unclear. This evidence concerns the gene CMTM6 and head and neck squamous cell carcinoma.