Comprehensive analysis, together with the pancreatic adenocarcinoma (PAAD) dataset from The Cancer Genome Atlas (TCGA), revealed that the ANTXR1, CMTM6, ITGB6, PIGR, and PTGS2 genes were significantly upregulated in GEM‐resistant PDAC cell lines (Figure 1C). Here, PTGS2 is linked to pancreatic adenocarcinoma.