CASP12 and infection: This was the case with the previously mentioned CASP12 gene, which harbours LoF alleles associated with reduced risk of infection and sepsis (Fischer et al. 2002; Yeretssian et al. 2009), or TLR5, whose deficiency was associated with reduced organ failure and improved survival in melioidosis (West et al. 2013) as well as with resistance to systemic lupus erythematosus (Hawn et al. 2005).