For instance, in a rat model of experimental autoimmune encephalomyelitis (EAE), GnRH administration significantly reduced NF-κB activation during disease progression and downregulated mRNA expression levels of the proinflammatory cytokines IL-1β, IL-17A, and TNF-α during the recovery phase60. This evidence concerns the gene GNRH1 and experimental autoimmune encephalomyelitis.