In this study, we found that in the methionine-restricted microenvironment, the expression levels of CXCL8 and VEGFA in glioma cells were significantly elevated, as well as CD31 and VEGFA levels in grafted tumor tissues, and the length of tubule-forming tubules and the number of nodes of tubule generation were significantly increased. This evidence concerns the gene PECAM1 and central nervous system cancer.