In summary, this study explored the relationship between methionine metabolic reprogramming and angiogenesis through a methionine-restricted resistant glioma cell model and identified CXCL8 and the CXCL8–CXCR2 signaling axis as positive regulators of methionine metabolism to promote angiogenesis in gliomas. Here, CXCR2 is linked to central nervous system cancer.